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Parareg (cinacalcet) - H05BX01

Updated on site: 09-Oct-2017

Naziv lijekaParareg
ATK šifraH05BX01
Tvarcinacalcet
ProizvođačDompé Biotec S.p.A.

What is Parareg?

Parareg is a medicine containing the active substance cinacalcet. It is available as light green oval tablets (30, 60 or 90 mg).

How is Parareg used?

In secon ary hyperparathyroidism, the recommended starting dose for adults is 30 mg once a day. The dose is adjusted every two to four weeks, according the patient’s PTH levels, up to a maximum of 180 mg once a day. PTH levels should be assessed at least 12 hours after dosing and one to four weeks after each dose adjustment of Parareg. Blood calcium levels should be measured frequently, and

calcium levels should be measured monthly and PTH levels should be measured every one to three months.

In patients with parathyroid carcinoma or primary hyperparathyroidism, the recommended starting dose of Parareg for adults is 30 mg twice a day. The dose of Parareg should be increased every two to four weeks up to 90 mg three or four times a day as necessary to reduce blood calcium to normal levels.

Parareg is taken with food or shortly after a meal.

How does Parareg work?

The active substance in Parareg, cinacalcet, is a calcimimetic agent. This means that it mimics the action of calcium in the body. Cinacalcet works by increasing the sensitivity of the calcium-sensing receptors on the parathyroid glands that regulate PTH secretion. By increasing the sensitivity of these receptors, cinacalcet leads to a reduction in the production of PTH by the parathyroid glands. The reduction in PTH levels also leads to a decrease in blood calcium levels.

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