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Refludan (lepirudin) - B01AE02

Updated on site: 09-Oct-2017

Naziv lijekaRefludan
ATK šifraB01AE02
Tvarlepirudin
ProizvođačCelgene Europe Ltd.

Refludan is a powder that is dissolved to make up a solution for inj ction or infusion (drip into a vein). It contains the active substance lepirudin.

What is Refludan used for?

Treatment with Refludan shou d be started by a doctor who has experience in the treatment of coagulation (clotting) disorders.

The recommended dose s 0.4 mg per kilogram body weight as a single injection into a vein, followed by a continuous infus on at a dose of 0.15 mg/kg per hour for two to 10 days, or longer if needed. The doses need to be redu ed in patients with kidney problems.

How does R fludan work?

Refludan is an antithrombotic medicine (a medicine that prevents the blood from clotting). The active substance in Refludan, lepirudin, is nearly identical to hirudin, the anti-clotting substance produced by leeches. Lepirudin specifically blocks a substance called thrombin, which is central for the complete process of blood clotting. By blocking thrombin, Refludan greatly reduces the risk of blood clots forming, preventing subsequent damage.

Lepirudin is produced by a method known as ‘recombinant DNA technology’: it is made by a cell that has received a gene (DNA), which makes it able to produce lepirudin.

How has Refludan been studied?

Refludan has been studied in two main studies involving 198 patients, 125 of whom had HIT and thromboembolic disease. The studies looked at the numbers of patients who died, had an amputation, and had new thromboembolic (clotting) complications. The studies did not compare Refludan with

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