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Zerene (zaleplon) - N05CF03

Updated on site: 11-Oct-2017

Naziv lijekaZerene
ATK šifraN05CF03
Tvarzaleplon
ProizvođačMeda AB

Zerene is a medicine that contains the active substance zaleplon. It is available as capsules (white and brown: 5 mg; white: 10 mg).

Treatment with Zerene should be as short as possible and should last for no more than two weeks. Zerene is taken immediately before going to bed, or after the patient has gone to bed and is having difficulty falling asleep. The ec mmended dose is 10 mg, except for the elderly and patients with mild or moderate liver disease, who should take 5 mg.

MedicinalThe maximum total dai y dose of Zerene is 10 mg. Patients should not take a second dose within a single night. No food shou d be eaten with or shortly before taking Zerene, because it can reduce the

medicine’s effects. Zerene must not be taken by children or by patients who have severe liver or kidney problems. For more information, see the Package Leaflet.

How does Zerene work?

The active substance in Zerene, zaleplon, belongs to a group of medicines that are related to the benzodiaz pines. Zaleplon is chemically different from the benzodiazepines, but it acts on the same rec ptors in the brain. It is a gamma-amino butyric acid (GABA) agonist, which means that it attaches to the receptors for the neurotransmitter GABA and activates them. Neurotransmitters such as GABA are chemicals that allow nerve cells to communicate with each other. In the brain, GABA is involved in bringing about sleep. By activating its receptors, zaleplon increases GABA’s effects, which encourages sleep.

The powder in Zerene capsules is coloured with an intense dark blue dye, to prevent it being given to someone without their knowledge.

How has Zerene been studied?

Zerene has been studied in a total of 14 studies, involving nearly 3,500 adults and elderly patients. Five of these studies were comparative: Zerene was compared with placebo (a dummy treatment) or with zolpidem or triazolam (other medicines used in insomnia). The main studies lasted for two to four weeks. The main measure of effectiveness was the time taken to fall asleep. Some studies also looked at the time spent asleep and sleeping patterns.

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